胃と腸48巻5号

2013年05月発行

特集 炎症性腸疾患 2013

主題 炎症性腸疾患の疫学・病因

炎症性腸疾患の病因

著者： 安藤朗¹

所属機関： ¹滋賀医科大学消化器内科

ページ範囲：P.555 - P.561

文献概要

炎症性腸疾患（IBD）は，遺伝的素因と環境因子の相互作用の結果，腸内細菌や食事抗原に対して，過剰な免疫応答が惹起され発症に至る．日本では，ここ数十年間にIBD患者が爆発的に増加した．日本人の遺伝的素因の変化は考えられず，腸内細菌をはじめとする環境因子の変化が，患者数の増加に関与していると推測される．本稿では，腸内細菌叢，自然免疫，獲得免疫とIBDの病態の関連について解説する．

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