胃と腸48巻5号

2013年05月発行

特集 炎症性腸疾患 2013

主題 炎症性腸疾患の疫学・病因

炎症性腸疾患の遺伝的背景

著者： 浅野光一¹ 梅野淳嗣¹ 松本主之¹

所属機関： ¹九州大学大学院病態機能内科学

ページ範囲：P.562 - P.568

文献概要

近年，炎症性腸疾患（IBD）におけるゲノム研究が進み，約160の関連遺伝子領域が同定された．しかしながら，人種差や環境の違いにより疾患関連遺伝子の影響度が異なることも明らかになっており，IBDの遺伝的要因に関する複雑な病態が改めて浮き彫りになっている．一方で，断片的とはいえ同定されたIBD関連遺伝子から新たなdisease pathwayを想定することが可能となり，病態解明の糸口や治療のターゲットになっている．さらに，遺伝子多型からみたIBDの発症，自然史，あるいは治療反応性の予測も試みられている．

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