胃と腸48巻5号

2013年05月発行

特集 炎症性腸疾患 2013 主題 炎症性腸疾患の経過

Crohn病の長期予後

著者： 江崎幹宏¹ 冬野雄太¹ 松本主之¹

所属機関： ¹九州大学大学院病態機能内科学

ページ範囲：P.716 - P.723

Crohn病（CD）は初期には腸管の炎症を認めるのみであるが，経過とともに狭窄・瘻孔・穿孔などの合併症を来し，腸管切除を余儀なくされる進行性の疾患である．従来の内科治療では，このようなCDの長期経過を改善することは困難とされてきた．しかし，抗TNF-α抗体製剤の登場により，高いレベルでの寛解維持を達成することが可能となった．なかでも，CD発症初期からの免疫調節薬や抗TNF-α抗体製剤の導入により，高度の腸管障害への進展を予防すれば，本症の自然経過を変えうることが証明されつつあり，腸管障害の側面からみたCDの長期予後は今後改善される可能性が高い．

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