胃と腸48巻9号

2013年08月発行

今月の主題 食道表在癌治療の最先端 主題研究

食道ESDに対する培養口腔粘膜上皮細胞シートの臨床応用

著者： 大木岳志¹² 大和雅之¹ 太田正穂² 高木亮¹ 近藤誠¹ 佐々木亮³ 金井信雄¹² 大脇敏之² 岡野光夫² 山本雅一¹

所属機関： ¹東京女子医科大学消化器外科 ²東京女子医科大学先端生命医科学研究所 ³東京女子医科大学歯科口腔外科

ページ範囲：P.1311 - P.1320

要旨　早期食道癌に対して低侵襲性治療であるESDが積極的に行われるようになってきた．ESDは大きさにかかわらず一括切除可能なため，ESD後の大きな潰瘍に起因する狭窄が問題となってきた．筆者らは，細胞シート工学技術を応用した再生医療的治療法を，動物実験段階から開発し，さらに臨床研究を進め，10症例経験してきた．患者の自己口腔粘膜組織を採取し，単離した口腔粘膜上皮細胞を温度応答性培養皿に播種，16日間培養する．培養口腔粘膜上皮細胞シートは低温処理のみで非侵襲的に回収することが可能で，それをESD直後の潰瘍面に経内視鏡的に移植する．本研究のように消化器領域の再生医療は始まったばかりで，癌治療分野での応用が期待される．

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