胃と腸52巻8号

2017年07月発行

今月の主題 臨床医も知っておくべき免疫組織化学染色のすべて

主題

上皮性腫瘍に対する免疫組織化学染色─胃腫瘍の免疫染色

著者： 九嶋亮治¹

所属機関： ¹滋賀医科大学臨床検査医学講座（附属病院病理診断科）

ページ範囲：P.997 - P.1009

文献概要

要旨●胃の上皮性腫瘍性病変の鑑別に有用な免疫染色法について，Ki-67とp53染色，形質発現を知るための分化マーカー染色，特殊型胃癌の染色，その他の重要な免疫染色の順に解説した．Ki-67とp53の染色ではその結果を過信せず，p53蛋白は領域性に強陽性を示すもののみ診断的価値がある．分化マーカーの発現に基づいた胃腫瘍の形質発現の解釈は，胃上皮の多分化能と腫瘍内多様性をよく理解したうえで行いたい．これらの免疫染色は一般型の胃癌や腺腫の診断では必須ではないが，特殊型胃癌の診断や転移性癌との鑑別には免疫染色による確認が必要となる．そのほか，胃腫瘍の診断に有用で一般の病理検査室で施行できる免疫染色について紹介する．

参考文献

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