胃と腸55巻10号

2020年09月発行

今月の主題 食道SM扁平上皮癌治療の新展開

主題

食道SM癌の治療選択—根治的CRTの立場から

著者： 伊藤芳紀¹ 小林玲¹ 村上幸三¹ 加藤正子¹ 今井敦¹ 師田まどか¹ 新城秀典¹ 新谷暁史¹ 小澤由季子¹ 豊福康介¹ 西村恵美¹ 関本篤人¹ 宮浦和徳¹ 加賀美芳和¹

所属機関： ¹昭和大学医学部放射線医学講座放射線治療学部門

ページ範囲：P.1273 - P.1282

文献概要

要旨●cStage I（cT1b）食道癌に対する根治的化学放射線療法（CRT）は，標準治療である外科的切除術を行わない場合に食道温存を図ることができる治療選択肢として食道癌診療ガイドラインで推奨されている．近年報告されたJCOG0502の結果，5年生存割合は食道切除術と差はなく，根治的CRTの大きな利点である5年食道温存生存割合が80.4%であることがわかった．課題として遅発性有害事象を増加させることなく，所属リンパ節領域の再発抑制が挙げられる．現在，予防的リンパ節領域照射（JCOG1904），強度変調放射線治療，陽子線治療や重粒子線治療などの粒子線治療，新規抗癌薬併用の治療開発が行われている．

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