胃と腸56巻10号

2021年09月発行

今月の主題 胃上皮性腫瘍—組織分類・内視鏡診断の新展開 主題研究

印環細胞癌の組織分類における最新知見

著者： 新井冨生¹

所属機関： ¹東京都健康長寿医療センター病理診断科

ページ範囲：P.1356 - P.1366

要旨●世界的に胃癌の発生率は減少しているものの，欧米では印環細胞癌の発生率が増加しているため印環細胞癌への関心が高まっている．印環細胞癌は，本邦の胃癌取扱い規約では一般型の一つとして分類されてきたが，WHO分類では第4版で一時的にpoorly cohesive carcinomaの一亜型とされたものの，第5版で独立した組織型として復活した．近年，欧州の研究グループが印環細胞癌の定義の曖昧さや病理診断の標準化の欠如を改善するために，印環型細胞の占める比率に基づく新たな定義を提唱した．まだ国際的にコンセンサスは得られていないが，今後印環細胞癌の診療や研究に影響を与えると思われる．また，層構造や腸型形質発現の有無と悪性度との関連，遺伝性胃癌など，印環細胞癌に関連する研究成果が近年注目されている．

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