icon fsr

文献詳細

雑誌文献

胃と腸56巻3号

2021年03月発行

文献概要

今月の主題 内視鏡医も知っておくべき病理診断リファレンス—下部消化管腫瘍 主題アトラス

空腸・回腸:小腸腺腫・腺癌

著者: 田中麻理子1 牛久哲男2

所属機関: 1東京大学医学部附属病院病理部 2東京大学医学系研究科人体病理学

ページ範囲:P.282 - P.287

文献購入ページに移動
概念・定義
 小腸は消化管粘膜表面積の9割以上を占めるが,腫瘍発生は比較的まれである1).国際疾病分類では,小腸はVater乳頭部と独立して分類され,十二指腸,空腸,回腸に区分される1).本稿では空腸・回腸に発生する腺腫と腺癌について解説する.

参考文献

1)Klimstra DS, Nagtegaal ID, Rugge M, et al. Tumours of the small intestine and ampulla. In WHO Classification of Tumours Editorial Board(ed). WHO Classification of Tumours, 5th ed. Digestive System Tumours. IARC press, Lyon, pp 111-126, 2019
2)Kiremitçi S, Cans?z Ersöz C, Sava? B, et al. Gastric and small intestinal traditional serrated adenomas:a detailed morphologic and immunohistochemical analysis. Turk J Gastroenterol 31:441-450, 2020
3)Rosty C, Campbell C, Clendenning M, et al. Do serrated neoplasms of the small intestine represent a distinct entity? Pathological findings and molecular alterations in a series of 13 cases. Histopathology 66:333-342, 2015
4)国立がん研究センター希少がんセンター.小腸がん(十二指腸がん・空腸がん・回腸がん).https://www.ncc.go.jp/jp/rcc/about/small_intestine_cancer/index.html(2021年1月25日閲覧)
5)Aparicio T, Henriques J, Manfredi S, et al. Small bowel adenocarcinoma:Results from a nationwide prospective ARCAD-NADEGE cohort study of 347 patients. Int J Cancer 147:967-977, 2020
6)Sakae H, Kanzaki H, Nasu J, et al. The characteristics and outcomes of small bowel adenocarcinoma:a multicentre retrospective observational study. Br J Cancer 117:1607-1613, 2017
7)Halfdanarson TR, McWilliams RR, Donohue JH, et al. A single-institution experience with 491 cases of small bowel adenocarcinoma. Am J Surg 199:797-803, 2010
8)Chang HK, Yu E, Kim J, et al. Adenocarcinoma of the small intestine:a multi-institutional study of 197 surgically resected cases. Hum Pathol 41:1087-1096, 2010
9)Jun SY, Kim M, Jin Gu M, et al. Clinicopathologic and prognostic associations of KRAS and BRAF mutations in small intestinal adenocarcinoma. Mod Pathol 29:402-415, 2016
10)Liao X, Li G, McBride R, et al. Clinicopathological and Molecular characterisation of Crohn's disease-associated small bowel adenocarcinomas. J Crohns Colitis 14:287-294, 2020
11)Fields AC, Hu FY, Lu P, et al. Small bowel adenocarcinoma:Is there a difference in survival for Crohn's Versus Sporadic Cases? J Crohns Colitis 14:303-308, 2020
12)Jun SY, Chung JY, Yoon N, et al. Tumor budding and poorly differentiated clusters in small intestinal adenocarcinoma. Cancers(Basel) 12:2199, 2020
13)Grolleau C, Pote NM, Guedj NS, et al. Small bowel adenocarcinoma complicating Crohn's disease:a single-centre experience emphasizing the importance of screening for dysplasia. Virchows Arch 471:611-617, 2017
14)Whitcomb E, Liu X, Xiao SY. Crohn enteritis-associated small bowel adenocarcinomas exhibit gastric differentiation. Hum Pathol 45:359-367, 2014
15)Arpa G, Grillo F, Giuffrida P, et al. Separation of low- versus high-grade Crohn's disease-associated small bowel carcinomas is improved by invasive front prognostic marker analysis. J Crohns Colitis 14:295-302, 2020
16)Rizzo F, Vanoli A, Sahnane N, et al. Small-bowel carcinomas associated with celiac disease:transcriptomic profiling shows predominance of microsatellite instability-immune and mesenchymal subtypes. Virchows Arch 476:711-723, 2020
17)Brcic I, Cathomas G, Vanoli A, et al. Medullary carcinoma of the small bowel. Histopathology 69:136-140, 2016
18)Kumagai R, Kohashi K, Takahashi S, et al. Mucinous phenotype and CD10 expression of primary adenocarcinoma of the small intestine. World J Gastroenterol 21:2700-2710, 2015
19)Schrock AB, Devoe CE, McWilliams R, et al. Genomic profiling of small-bowel adenocarcinoma. JAMA Oncol 3:1546-1553, 2017
20)Hänninen UA, Katainen R, Tanskanen T, et al. Exome-wide somatic mutation characterization of small bowel adenocarcinoma. PLoS Genet 14:e1007200, 2018
21)Salem ME, Puccini A, Grothey A, et al. Landscape of tumor mutation load, mismatch repair deficiency, and PD-L1 expression in a large patient cohort of gastrointestinal cancers. Mol Cancer Res 16:805-812, 2018
22)Wirta EV, Szeto S, Hänninen U, et al. Prognostic value of immune environment analysis in small bowel adenocarcinomas with verified mutational landscape and predisposing conditions. Cancers(Basel) 12:2018, 2020
23)Vanoli A, Di Sabatino A, Biancone L, et al. Small bowel Epstein-Barr virus-positive lympho-epithelioma-like carcinoma in Crohn's disease. Histopathology 70:837-839, 2017

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1219

印刷版ISSN:0536-2180

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?