胃と腸57巻2号

2022年02月発行

今月の主題 炎症性腸疾患の粘膜治癒を再考する 主題

Crohn病における全層性炎症評価の意義—MREの立場から

著者： 佐上晋太郎¹² 鈴木敏司³ 小林拓¹²

所属機関： ¹北里大学北里研究所病院炎症性腸疾患先進治療センター ²北里大学北里研究所病院消化器内科 ³北里大学北里研究所病院中央放射線科

ページ範囲：P.191 - P.200

要旨●Crohn病において内視鏡的粘膜治癒の達成を目指した治療戦略は，持続的な長期臨床的寛解を実現する治療目標として重要視されてきた．しかしながらCrohn病は全層性炎症であることから，MREなどのcross sectional imagingによる全層性炎症の消失は表層性の炎症消失を意味する内視鏡的粘膜治癒よりも良好な予後と相関することが報告されている．今後MREなどによる疾患のモニタリングが確立していくことで，疾患の経過をさらに改善し不可逆的な腸の損傷を防ぐことが期待される．

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