ログイン
ランキング
お知らせ
ログイン
文献詳細
今月の主題 特殊型胃癌—組織発生と内視鏡診断
主題
文献概要
要旨●胃癌の組織型は，胃癌取扱い規約において一般型と特殊型に分類されている．特殊型胃癌はいずれもまれなものであるが，病理組織学的に腫瘍細胞の充実性増殖を示すものが多く，低分化腺癌充実型，悪性リンパ腫，肉腫などとの鑑別が必要となる．また，臨床的にも予後が著明に不良なものや一般型胃癌よりも予後良好なものがあり，特殊型であっても組織型の特定は重要である．本稿では，特殊型胃癌の各組織型について発生機序を含めた臨床病理学的特徴を網羅的に示した．
参考文献
1）日本胃癌学会（編）．胃癌取扱い規約，第15版．金原出版．2017
2）Rindi G, Luinetti O, Cornaggia M, et al. Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma：a clinicopathologic study. Gastroenterology 104：994-1006, 1993
3）Ooi A, Ota M, Katsuda S, et al. An unusual case of multiple gastric carcinoids associated with diffuse endocrine cell hyperplasia and parietal cell hypertrophy. Endocr Pathol 6：229-237, 1995
4）Masui T, Ito T, Komoto I, et al. Recent epidemiology of patients with gastro-entero-pancreatic neuroendocrine neoplasms（GEP-NEN）in Japan：a population-based study. BMC Cancer 20：1104, 2020
5）Mastracci L, Rindi G, Grillo F, et al. Neuroendocrine neoplasms of the esophagus and stomach. Pathologica 113：5-11, 2021
6）海崎泰治．上部消化管：カルチノイド腫瘍・内分泌細胞癌．胃と腸 55：450-454, 2020
7）La Rosa S, Inzani F, Vanoli A, et al. Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms. Hum Pathol 42：1373-1384, 2011
8）Vanoli A, La Rosa S, Miceli E, et al. Prognostic evaluations tailored to specific gastric neuroendocrine neoplasms：analysis of 200 cases with extended follow-up. Neuroendocrinology 107：114-126, 2018
9）海崎泰治，小上瑛也，原季衣，他．消化管内分泌細胞腫瘍の病理学的特徴．胃と腸 52：390-401, 2017
10）日本胃癌学会．胃がん学会全国登録解析結果報告—2013年手術症例．http://www.jgca.jp/entry/iganhtml/doc/2013_report_.pdf（2022年4月22日閲覧）
11）海崎泰治，細川治，浅海吉傑，他．消化管内分泌細胞腫瘍の病理学的特徴—上部消化管（食道・胃・十二指腸）を中心に．胃と腸 48：957-970, 2013
12）Milione M, Maisonneuve P, Pellegrinelli A, et al. Ki67 proliferative index of the neuroendocrine component drives MANEC prognosis. Endocr Relat Cancer 25：583-593, 2018
13）岩渕三哉，渡辺英伸，石原法子，他．消化管のカルチノイドと内分泌細胞癌の病理—その特徴と組織発生．臨消内科 5：1669-1681, 1990
14）海崎泰治，細川治，宮永太門，他．リンパ球浸潤胃癌—病理の立場から．胃と腸 45：1916-1925, 2010
15）Watanabe H, Enjoji M, Imai T. Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations. Cancer 38：232-243, 1976
16）神崎洋光，飯石浩康，長井健悟，他．リンパ球浸潤胃癌—臨床の立場から．胃と腸 45：1926-1934, 2010
17）Lim H, Lee IS, Lee JH, et al. Clinical application of early gastric carcinoma with lymphoid stroma based on lymph node metastasis status. Gastric Cancer 20：793-801, 2017
18）宮永太門，海崎泰治，細川治，他．特殊型胃癌の臨床的特徴—胃癌取扱い規約第14版をうけて．胃と腸 45：1882-1893, 2010
19）Ushiku T, Uozaki H, Shinozaki A, et al. Glypican-3-expressing gastric carcinoma：distinct subgroup unifying hepatoid, clear-cell, and alpha-fetoprotein-producing gastric carcinomas. Cancer Sci 100：626-632, 2009
20）Ushiku T, Shinozaki A, Shibahara J, et al. SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma. Am J Surg Pathol 34：533-540, 2010
21）Nagai E, Ueyama T, Yao T, et al. Hepatoid adenocarcinoma of the stomach. A clinicopathologic and immunohistochemical analysis. Cancer 72：1827-1835, 1993
22）Yamazawa S, Ushiku T, Shinozaki-Ushiku A, et al. Gastric cancer with primitive enterocyte phenotype：an aggressive subgroup of intestinal-type adenocarcinoma. Am J Surg Pathol 41：989-997, 2017
23）鈴木晴久，小田一郎，吉永繁高，他．肝様腺癌—臨床の立場から．胃と腸 45：1941-1949, 2010
24）Murakami T, Yao T, Mitomi H, et al. Clinicopathologic and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation：a study of 29 cases. Gastric Cancer 19：498-507, 2016
25）Matsunou H, Konishi F, Jalal RE, et al. Alpha-fetoprotein-producing gastric carcinoma with enteroblastic differentiation. Cancer 73：534-540, 1994
26）He F, Fu Y, Sun Q, et al. Integrated clinicopathological and immunohistochemical analysis of gastric adenocarcinoma with hepatoid differentiation：an exploration of histogenesis, molecular characteristics, and prognostic markers. Hum Pathol 115：37-46, 2021
27）Ueyama H, Matsumoto K, Nagahara A, et al. Gastric adenocarcinoma of the fundic gland type（chief cell predominant type）. Endoscopy 46：153-157, 2014
28）八板弘樹，蔵原晃一，大城由美，他．胃底腺型胃癌の臨床的特徴—X線・内視鏡所見を中心に．胃と腸 50：1493-1506, 2015
29）上山浩也，松本紘平，八尾隆史，他．H. pylori未感染上皮性腫瘍の内視鏡的特徴—胃底腺型胃癌．胃と腸 55：1006-1021, 2020
30）Ueyama H, Yao T, Nakashima Y, et al. Gastric adenocarcinoma of fundic gland type（chief cell predominant type）：proposal for a new entity of gastric adenocarcinoma. Am J Surg Pathol 34：609-619, 2010
31）上山浩也，八尾隆史，渡辺純夫．胃底腺型胃癌の臨床病理学的特徴．Gastroenterol Endosc 57（Supple 2）：2048, 2015
32）太田博俊，豊田澄男，岡野光伸，他．胃の腺扁平上皮癌．癌の臨 24：1287-1294, 1978
33）谷口浩和．扁平上皮癌・腺扁平上皮癌．深山正久，大倉康男（編）．腫瘍病理鑑別診断アトラス—胃癌，第2版．文光堂，pp 124-128, 2015
34）山際裕史．胃腸管におけるAdenosquamous cell carcinoma（1）胃．臨病理 33：674-678, 1985
35）前田将宏，谷口浩和，関根茂樹，他．胃腺扁平上皮癌の臨床病理学的研究．胃と腸 45：1959-1966, 2010
36）Agaimy A, Daum O, Märkl B, et al. SWI/SNF complex-deficient undifferentiated/rhabdoid carcinomas of the gastrointestinal tract：a series of 13 cases highlighting mutually exclusive loss of SMARCA4 and SMARCA2 and frequent co-inactivation of SMARCB1 and SMARCA2. Am J Surg Pathol 40：544-553, 2016
37）Ueyama T, Nagai E, Yao T, et al. Vimentin-positive gastric carcinomas with rhabdoid features. A clinicopathologic and immunohistochemical study. Am J Surg Pathol 17：813-819, 1993
38）Utsunomiya T, Yao T, Masuda K, et al. Vimentin-positive adenocarcinomas of the stomach：co-expression of vimentin and cytokeratin. Histopathology 29：507-516, 1996
39）松尾祐太，石橋雄次，神田聡，他．Rhabdoid featureを呈した胃未分化癌の1例．日臨外会誌 79：2265-2269, 2018
40）Liu AY, Chan WY, Ng EK, et al. Gastric choriocarcinoma shows characteristics of adenocarcinoma and gestational choriocarcinoma：a comparative genomic hybridization and fluorescence in situ hybridization study. Diagn Mol Pathol 10：161-165, 2001
41）Kobayashi A, Hasebe T, Endo Y, et al. Primary gastric choriocarcinoma：two case reports and a pooled analysis of 53 cases. Gastric Cancer 8：178-185, 2005
42）海上雅光，広田映五，板橋正幸，他．胃原発悪性絨毛性腫瘍の3例．癌の臨 28：204-210, 1982
43）増田亮，磯山徹，板東隆文，他．胃原発絨毛癌の1例—本邦例45例の文献的考察．癌の臨 36：1025-1030, 1990
44）Imai Y, Kawabe T, Takahashi M, et al. A case of primary gastric choriocarcinoma and a review of the Japanese literature. J Gastroenterol 29：642-646, 1994
45）Shioya A, Kurose N, Mizutani K, et al. Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence：a case report. Diagn Pathol 15：118, 2020
46）Kuroda H, Saito H, Kono Y, et al. Carcinosarcoma of stomach confined to the mucosa. Yonago Acta Med 60：246-250, 2018
47）Nie L, Zhou X, Peng L, et al. Histological heterogeneity and distributional difference of gastric carcinosarcoma：report of 4 cases and literature review. Pol J Pathol 69：366-375, 2018
48）Shimoda M, Okada Y, Hayashi Y, et al. Primary invasive micropapillary carcinoma of the stomach. Pathol Int 58：513-517, 2008
49）Eom D-W, Kang GH, Han SH, et al. Gastric micropapillary carcinoma：A distinct subtype with a significantly worse prognosis in TNM stages I and II. Am J Surg Pathol 35：84-91, 2011
50）Zhang Q, Ming J, Zhang S, et al. Micropapillary component in gastric adenocarcinoma：an aggressive variant associated with poor prognosis. Gastric Cancer 18：93-99, 2015
51）Ushiku T, Matsusaka K, Iwasaki Y, et al. Gastric carcinoma with invasive micropapillary pattern and its association with lymph node metastasis. Histopathology 59：1081-1089, 2011
52）Fujita T, Gotohda N, Kato Y, et al. Clinicopathological features of stomach cancer with invasive micropapillary component. Gastric Cancer 15：179-187, 2012
53）Cheng Y, Du M, Wang Y, et al. Micropapillary early gastric carcinoma with distinct clinicopathological features, high risk for lymph node metastasis, and dismal prognosis：a multicenter clinicopathological study of 29 cases identified in 1890 early gastric carcinoma radical gastrectomies. Hum Pathol 83：149-158, 2019
54）Kano M, Hihara J, Kaneko M, et al. Gastrectomy for invasive micropapillary carcinoma is associated with poorer disease-free and disease-specific survival. Int J Clin Oncol 24：1565-1573, 2019
55）Roh JH, Srivastava A, Lauwers GY, et al. Micropapillary carcinoma of stomach：a clinicopathologic and immunohistochemical study of 11 cases. Am J Surg Pathol 34：1139-1146, 2010
掲載誌情報
