胃と腸57巻9号

2022年08月発行

今月の主題 胃癌スクリーニングの課題と将来展望 主題研究

背景胃粘膜の病理組織学的所見

著者： 和田康宏¹² 九嶋亮治² 向所賢一³ 兒玉雅明¹⁴ 渕野貴文¹ 福田昌英¹ 水上一弘¹ 沖本忠義¹ 村上和成¹

所属機関： ¹大分大学医学部消化器内科学講座 ²滋賀医科大学医学部病理学講座（附属病院病理診断科） ³滋賀医科大学医学部医学・看護学教育センター ⁴大分大学福祉健康科学部

ページ範囲：P.1175 - P.1185

要旨●H. pylori感染に伴い胃粘膜に生じる化生として，腸上皮化生，幽門腺化生・偽幽門腺化生，膵上皮化生が知られている．腸上皮化生は免疫組織化学的に完全型腸上皮化生と不完全型腸上皮化生に分類される．本稿では免疫組織化学染色を行い，H. pylori除菌による完全型腸上皮化生・不完全型腸上皮化生，幽門腺化生・偽幽門腺化生，膵上皮化生の可逆性について検討した．その結果，不完全型腸上皮化生，幽門腺化生・偽幽門腺化生の出現頻度が除菌により有意に低下した．近年，除菌後にも胃癌が発生することが問題となり，除菌後胃癌の高リスク患者の特定が必要となっているが，これらの化生の減少が除菌後胃癌の予防に寄与する可能性があり，今後の検討課題である．

参考文献

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