胃と腸58巻1号

2023年01月発行

今月の主題 Non-H. pylori Helicobacter胃炎と周辺疾患 主題

NHPHの歴史的推移と疫学

著者： 中村正彦¹ 高橋信一² 松久威史³ 山岡吉生⁴ 松井英則⁵ 村山琮明⁶ 鈴木秀和⁷

所属機関： ¹東海大学医学部 ²杏林大学医学部 ³聖マリアンナ医科大学東横病院消化器内科 ⁴大分大学医学部環境予防医学講座 ⁵国立感染症研究所細菌第二部 ⁶国立感染症研究所真菌部 ⁷東海大学医学部附属病院消化器内科

ページ範囲：P.13 - P.26

要旨●NHPHは，検出法，培養が困難であったこともあり，H. pyloriの影に隠れてきた側面がある．しかし，19世紀後半には動物の胃内の螺旋菌の存在が報告され，20世紀前半にはヒトの胃粘膜内に数種の螺旋菌の存在が報告されており，H. pyloriおよびNHPHの推定が可能となった．1987年以降は，症例報告が積み重なり，疾患との関係や自然宿主について明らかになってきた．遺伝子解析などにより明確な診断や病原因子の解明が実現し，H. pyloriとの違いも明らかとなりつつある．

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