臨床整形外科42巻1号

2007年01月発行

誌上シンポジウム 変形性膝関節症―最近の進歩

変形性関節症の発症原因

著者： 福井尚志¹

所属機関： ¹国立病院機構相模原病院臨床研究センター病態総合研究部

ページ範囲：P.17 - P.22

　変形性関節症（OA）は運動器領域の代表的なcommon diseaseであるため疾患の進行のメカニズムについては多くの研究がなされ，様々な知見が得られている．しかしOAの狭義の発症のメカニズムについては研究が困難なこともあり，まだ不明な点が多く残されている．本稿では疫学的研究によりOA発症の危険性を増すことが知られている年齢，肥満，性について疾患発症とどのように関連するのか現在までに知られていることを述べ，さらに最近新たな知見が相次いで報告されているOAの遺伝的要因についても触れる．

参考文献

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