臨床整形外科44巻12号

2009年12月発行

最新基礎科学／知っておきたい

コラーゲン架橋

著者： 斎藤充¹ 丸毛啓史¹

所属機関： ¹東京慈恵会医科大学整形外科

ページ範囲：P.1218 - P.1224

■はじめに

　コラーゲン架橋とは，コラーゲンの分子間をつなぎ止める構造体(共有結合)のことである．コラーゲン架橋に関する研究は，本邦においても30年以上前に整形外科医を中心に盛んに基礎研究が行われていた．しかし，当時は数あるコラーゲン架橋のうち一部の構造体のみしか同定されていなかった．このためコラーゲン架橋の生物学的な機能の解明は進まず，この分野の研究は廃れてしまった．しかし，その後，成熟型のピリジノリン架橋や，老化型架橋である最終糖化/酸化生成物(advanced glycation end products；AGEs)といった架橋構造体が同定され，コラーゲンにおける架橋形成の生物学的意義が次々と明らかにされ，臨床につながる基礎研究として新たな時代を迎えるに至っている^18）．そこで，本稿では，コラーゲン架橋の代表的機能である骨強度規定因子(骨質因子)としての役割と，その臨床的意義について述べたい．

参考文献

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