臨床整形外科44巻4号

2009年04月発行

最新基礎科学／知っておきたい

脊髄の軸索再生を制御する分子群

著者： 山下俊英¹

所属機関： ¹大阪大学大学院医学系研究科分子神経科学

ページ範囲：P.378 - P.380

■はじめに

　軸索再生阻害因子と呼ばれる複数の蛋白質が中枢神経回路の安定性を保つ役割を担っていることが示唆されている．脊髄損傷などの疾患により中枢神経回路がひとたび破壊されると，修復は極めて困難となるが，その原因として軸索再生阻害因子の存在があげられる．近年これらの因子群とそのシグナル伝達機構が明らかになってきた．本欄では「中枢神経の再生しにくさ」の分子メカニズムについて概説し，最近試みられている治療的展開を紹介する．

参考文献

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