臨床整形外科45巻2号

2010年02月発行

論述

悪性骨軟部腫瘍の治療効果判定における^99mTc-MIBIシンチグラムの有用性の検討―²⁰¹Tlシンチグラム，血管造影との比較

著者： 三輪真嗣¹ 土屋弘行¹ 白井寿治¹ 林克洋¹ 大成一誓¹ 富田勝郎¹ 滝淳一²

所属機関： ¹金沢大学大学院医学研究科整形外科 ²金沢大学大学院医学系研究科バイオトレーサー診療学

ページ範囲：P.157 - P.163

　悪性骨軟部腫瘍の64例に対し，^99mTc-MIBI，²⁰¹Tl，血管造影を施行し，化学療法の効果を判定した．^99mTc-MIBI，²⁰¹Tlのuptake ratioの％reductionと血管造影での評価を病理組織学的評価と比較した．血管造影像で新生血管を消失(CR)，減少(PR)，不変(NC)，増大(PD)に分類し，CRとPRを反応群とした．^99mTc-MIBIでは％reduction25％以上を反応群，²⁰¹Tlでは％reduction30％以上を反応群とした．すべての症例において切除標本を病理組織学的に評価し，壊死率90％以上を反応群とした．感度，特異度，正確度は^99mTc-MIBIで86.7％，91.2％，89.1％，²⁰¹Tlで80.0％，70.6％，75.0％，血管造影で86.7％，38.2％，60.9％であった．悪性骨軟部腫瘍に対する化学療法の効果判定において^99mTc-MIBIは最も有用な検査であると考えた．

参考文献

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