臨床整形外科45巻9号

2010年09月発行

誌上シンポジウム 軟骨再生―基礎と臨床

変形性膝関節症に対するグルコサミンの経口投与

著者： 榎本宏之¹ 松本秀男²

所属機関： ¹慶應義塾大学整形外科 ²慶應義塾大学スポーツ医学総合センター

ページ範囲：P.773 - P.777

　近年，変形性膝関節症(OA)の治療体系で，グルコサミンの効果が期待されている．In vivo，in vitroにおける軟骨基質産生促進作用や抗炎症作用，基質分解抑制作用が報告されているが，OA患者に対するランダム比較検討試験ではグルコサミン塩酸塩とグルコサミン硫酸塩で相反する結果が報告されている．少なくとも費用対効果の面で，グルコサミンの効果が臨床上でどの程度有用であるか，いまだに疑問が残る．われわれは日本人に対するグルコサミン塩酸塩の効果を検討しており，その最終結果を2011年の日本整形外科学会術総会で発表する予定である．

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