臨床整形外科45巻9号

2010年09月発行

誌上シンポジウム 軟骨再生―基礎と臨床

滑膜間葉幹細胞の鏡視下移植術

著者： 関矢一郎¹ 宗田大²

所属機関： ¹東京医科歯科大学大学院軟骨再生学 ²東京医科歯科大学大学院運動器外科学

ページ範囲：P.791 - P.795

　軟骨組織は細胞密度が低く，血行を欠くことから，再生能力が低い．そのため軟骨欠損部に対して細胞成分を補うことが，軟骨を再生させるための手段の一つになる．細胞源として間葉幹細胞は有用であるが，なかでも滑膜由来のものは軟骨分化能が高く，自己血清を用いて優れた増殖を示す．滑膜間葉幹細胞の浮遊液を軟骨欠損部に10分間静置すると約6割の細胞が接着し，軟骨修復を促進させることが実験的に示されている．これまでの基礎研究の成果を基にして，滑膜間葉幹細胞を関節鏡視下で移植する軟骨再生医療を開始している．重篤な副作用を認めず，多数の例で軟骨欠損部の再生，症状の改善を認めている．

参考文献

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