臨床整形外科47巻1号

2012年01月発行

誌上シンポジウム 整形外科領域における蛍光イメージング

腫瘍　腫瘍細胞のリアルタイムイメージング

著者： 山本憲男¹ 林克洋² 山内健輔² 木村浩明² ロバート・ホフマン³⁴ 土屋弘行²

所属機関： ¹金沢大学大学院地域医療救急・整形外科学講座 ²金沢大学大学院医学系研究科機能再建学講座 ^{3 4}

ページ範囲：P.17 - P.25

　がんに対する研究はこれまでも精力的に行われ，毎年多くの研究成果が報告されているが，その大多数は断片的なもので，腫瘍細胞の経時的な変化について観察したものは少ない．われわれは，蛍光蛋白遺伝子を腫瘍細胞内へ導入することで，in vivoにおいても腫瘍細胞をsingle cellレベルでリアルタイムに観察できる各種モデルを作製してきた．これらモデルは，遺伝子機能解析や新規抗がん剤開発などに非常に有用なものであり，これらモデルの概略を紹介する．

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