臨床整形外科48巻10号

2013年10月発行

誌上シンポジウム 低出力超音波パルス（LIPUS）による骨折治療―基礎と臨床における最近の話題 臨床応用における基礎研究

遷延骨癒合・偽関節に対する経皮的濃縮自家骨髄血移植と低出力超音波パルス併用による治療効果

著者： 三島初¹ 菅谷久¹ 青戸克哉¹ 吉岡友和¹ 酒井晋介¹ 赤荻博¹ 落合直之¹ 山崎正志¹

所属機関： ¹筑波大学医学医療系整形外科

ページ範囲：P.961 - P.968

　治療に難渋する骨癒合不全に対し，低出力超音波パルス(LIPUS)を併用した骨髄血移植の治療効果を検討した．施行27症例のうち治療後1年以上経過した17症例(大腿骨10例，脛骨5例，上腕骨1例，尺骨1例)を対象とした．平均年齢は40.7歳で，全例萎縮性変化を伴っていた．12カ月での癒合率は全体で76％，下肢長幹骨では87％であった．本手法は骨新生の材料となる骨髄細胞・成長因子を十分供給し，なおかつLIPUSが初期の分化促進に効果的に作用し骨癒合反応再開に寄与したと考えられる．低侵襲・安全・低コストな本手法は，骨癒合不全に対する有用な治療方法の選択枝の1つであると考えている．

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