臨床整形外科48巻12号

2013年12月発行

誌上シンポジウム 慢性疼痛と原因療法―どこまで追究が可能か

慢性疼痛におけるグリア細胞の関与と治療応用への可能性

著者： 津田誠¹ 井上和秀¹

所属機関： ¹九州大学大学院薬学研究院薬理学分野

ページ範囲：P.1185 - P.1190

　神経系のダメージにより慢性的な痛み「神経障害性疼痛」が発症するが，その発症・維持メカニズムはわかっていない．従来までは，神経障害性ゆえに，神経での変化のみが注目され，研究が行われてきたが，最近の研究から，神経の損傷後にグリア細胞が著しく活性化し，さまざまな機能分子を発現して，神経障害性疼痛の発症・維持に重要な役割を担っていることが明らかになってきた．本総説では，これらのグリア細胞，特にミクログリアに注目した研究成果を紹介し，それらの知見からみえてきた新しい神経障害性疼痛の細胞分子メカニズムを概説する．

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