臨床整形外科49巻11号

2014年11月発行

誌上シンポジウム 運動器画像診断の進歩

MRIによる関節軟骨評価の進歩

著者： 渡辺淳也¹

所属機関： ¹千葉大学大学院医学研究院整形外科学

ページ範囲：P.953 - P.958

　MRIは関節軟骨の評価における中心的なモダリティであり，軟骨の損傷や変性の診断に極めて有用である．近年，MRI機器や撮像技術の進歩に伴い，より高い信号雑音比，より高い空間分解能での形態評価が可能となってきた．また軟骨中の分子構造変化を鋭敏にとらえることが可能な新しいMRI評価法が臨床応用されつつあり，軟骨変性の早期診断や軟骨変性度の定量的評価に有用な方法として期待される．今後，変形性関節症に対する予防医学の発展や軟骨損傷に対する再生医療技術の進歩などに伴い，軟骨の詳細な形態的，質的MRI診断の重要性はさらに高まるものと考えられる．

参考文献

1) Bashir A, Gray ML, Burstein D, et al:Gd-DTPA2- as a measure of cartilage degradation. Magn Reson Med 36:665-673, 1996

2) Borthakur A, Mellon E, Niyogi S, et al:Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage. NMR Biomed 19:781-821, 2006

3) Burstein D, Velyvis J, Scott KT, et al:Protocol issues for delayed Gd (DTPA) (2-) -enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage. Magn Reson Med 45:36-41, 2001

4) Bydder M, Rehal A, Fullerton GD, et al:The magic angle effect:a source of artifact, determinant of image contrast, and technique for imaging. J Magn Reson Imaging 25:290-300, 2007

5) Chen CA, Kijowski R, Shapiro LM, et al:Cartilage morphology at 3.0T:assessment of three-dimensional magnetic resonance imaging techniques. J Magn Reson Imaging 32:173-183, 2010

6) Deng X, Farley M, Nieminen MT, et al:Diffusion tensor imaging of native and degenerated human articular cartilage. Magn Reson Imaging 25:168-171, 2006

7) Kijowski R, Davis KW, Woods MA, et al:Knee joint:comprehensive assessment with 3D isotropic resolution fast spin-echo MR imaging--diagnostic performance compared with that of conventional MR imaging at 3.0 T. Radiology 252:486-495, 2009

8) Nieminen MT, Rieppo J, Törräs J, et al:T2 relaxation reveals spatial collagen architecture in articular cartilage:a comparative quantitative MRI and polarized light microscopic study. Magn Reson Med 46:487-493, 2001

9) Siversson C, Tiderius CJ, Neuman P, et al:Repeatability of T1-quantification in dGEMRIC for three different acquisition techniques:two-dimensional inversion recovery, three-dimensional look locker, and three-dimensional variable flip angle. J Magn Reson Imaging 31:1203-1209, 2010

10) Taylor C, Carballido-Gamio J, Majumdar S, et al:Comparison of quantitative imaging of cartilage for osteoarthritis:T2, T1rho, dGEMRIC and contrast-enhanced computed tomography. Magn Reson Imaging 27:779-784, 2009

11) Watanabe A, Boesch C, Siebenrock K, et al:T2 mapping of hip articular cartilage in healthy volunteers at 3T:a study of topographic variation. J Magn Reson Imaging 26:165-171, 2007

12) Wheaton AJ, Casey FL, Gouquotas AJ, et al:Correlation of T1rho with fixed charge density in cartilage. J Magn Reson Imaging 20:519-525, 2004

13) Yoshioka H, Steves K, Hargreaves BA, et al:Magnetic resonance imaging of articular cartilage of the knee:comparison between fat-supressed FSE imaging and correlation with arthoroscopy. J Magn Reson Imaging 20:857-864, 2004