臨床整形外科49巻12号

2014年12月発行

調査報告

高齢者慢性腰痛症に対する薬物療法—プレガバリンとオピオイドの比較

著者： 酒井義人¹ 原田敦¹ 伊藤定之¹

所属機関： ¹国立長寿医療研究センター整形外科

ページ範囲：P.1071 - P.1079

　背景：慢性腰痛症の薬物療法ではプレガバリンやオピオイドの有効性が報告される一方，副作用も少なくなく高齢者に対する投与は慎重に行われるべきである．

　対象と方法：非ステロイド性抗炎症薬(NSAIDs)無効例の65歳以上の慢性腰痛症65例に対するプレガバリンとオピオイドの効果を評価した．

　結果：両薬剤の効果には差がなかったが，効果発現時期はプレガバリン10.2日，オピオイド6.1日で有意差を認めた．プレガバリンは神経障害性疼痛に，オピオイドは非神経障害性疼痛に有効であった．

　まとめ：神経障害性疼痛を評価することにより，プレガバリンとオピオイドの使い分けが可能である．

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