臨床整形外科50巻4号

2015年04月発行

臨床経験

トラネキサム酸による空気止血帯非使用人工膝関節全置換術の輸血率の低減

著者： 大岩美奈子¹ 塚田幸行² 涌井元博²

所属機関： ¹猫山宮尾病院薬剤科 ²猫山宮尾病院整形外科

ページ範囲：P.375 - P.378

　人工膝関節全置換術(total knee arthroplasty，TKA)症例を，トラネキサム酸(tranexamic acid，TA)を投与した63症例と投与しなかった69症例に分け，出血量と輸血率を比較した．TAは手術開始直前とその6時間後に1,000mgを点滴静脈内注射した．術中出血量は投与群199.4mL：非投与群285.2mL(p＝0.0030)，総出血量は投与群996.3mL：非投与群1,285.9mL(p＜0.0001)だった．輸血率は，投与群1.6％：非投与群10.1％(p＝0.040)だった．TA投与によりTKA時の出血量と輸血率の低減が得られた．

参考文献

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