臨床整形外科51巻3号

2016年03月発行

誌上シンポジウム 半月変性断裂に対する治療

半月変性断裂に対する細胞治療の試み

著者： 中川裕介¹ 宗田大² 関矢一郎¹

所属機関： ¹東京医科歯科大学再生医療研究センター ²東京医科歯科大学大学院運動器外科学

ページ範囲：P.247 - P.253

　半月は治癒能力が低く，縫合術は適応が限定され，再断裂などの問題もある．特に半月変性断裂では縫合術の成績は悪く，切除術の適応とされる．われわれは滑膜由来間葉系幹細胞(滑膜幹細胞)は増殖・軟骨分化能が高く，移植により半月の再生が促進されることを示してきた．今回，前臨床試験として，ピッグの内側半月無血行野に縦断裂を作製し縫合後，滑膜幹細胞を局所投与し，損傷部の治癒が促進されるか検討した．この結果に基づき，2014年8月から一般的には切除術の適応となる半月変性断裂に対する臨床試験を実施した．安全性を確認し，現在その有効性を検討している．

参考文献

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