臨床整形外科53巻1号

2018年01月発行

誌上シンポジウム 脂肪幹細胞と運動器再生

脂肪由来間質細胞による脊髄損傷治療

著者： 髙橋藍¹ 中嶋秀明¹ 山本悠介¹ 松峯昭彦¹

所属機関： ¹福井大学医学部器官制御医学講座整形外科学領域

ページ範囲：P.7 - P.12

　脂肪由来間質細胞(adipose-derived mesenchymal stromal cell；ADSC)は採取が比較的容易であり，幹細胞の頻度も高いと報告されており，脊髄損傷に対するADSC移植による運動機能改善効果，軸索再生効果が認められた．また，脊髄損傷部では二次損傷による虚血，炎症，酸化ストレスが惹起され移植細胞に影響すると考えられるが，ADSCは酸化ストレスや低酸素に対する抵抗性が認められ，移植後の生存率も高いことから，質的な面での有用性も期待される．

参考文献

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