臨床整形外科53巻1号

2018年01月発行

誌上シンポジウム 脂肪幹細胞と運動器再生

脂肪由来幹細胞と骨再生

著者： 林克洋¹ 野村一世¹ 方向¹ 土屋弘行¹

所属機関： ¹金沢大学大学院医薬保健学総合研究科・整形外科学講座

ページ範囲：P.21 - P.25

　幹細胞や成長因子などを使用した骨の再生医療は古くから行われてきており，一定の成果を収めている．間葉系幹細胞の1つである脂肪由来幹細胞は骨にも分化し，ヒトでも侵襲が少なく十分な細胞数が得られるので，骨再生の臨床応用が現実的である．当科でもin vivoで仮骨延長への移植実験を行い，旺盛な骨形成を認めた．また，in vitroでアスコルビン酸を用いた脂肪由来幹細胞シートの作成に成功し，非シート細胞に比べ骨分化能に優れていることがわかった．

参考文献

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