臨床整形外科53巻11号

2018年11月発行

誌上シンポジウム 椎間板研究の最前線

椎間板変性と疼痛

著者： 宮城正行¹

所属機関： ¹北里大学医学部整形外科学

ページ範囲：P.945 - P.950

　椎間板は腰痛の原因組織として考えられているが，通常の加齢性の変化で起こる椎間板変性が必ずしも慢性化する腰痛を来すわけではない．過去の基礎・臨床研究結果から，椎間板変性の過程で起こる椎間板内層への神経侵入と神経感作，椎間板内に発現する疼痛関連物質，椎間板に加わるメカニカルストレスが椎間板由来の慢性的な腰痛の発症において重要と考えられる．そのため，椎間板由来の腰痛の慢性化を防ぐためには，腰痛急性期における適切な安静と適切な薬物治療により，慢性化する前に最大限“芽を摘む”ことが重要なのではないかと筆者は考えている．

参考文献

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