臨床整形外科53巻11号

2018年11月発行

誌上シンポジウム 椎間板研究の最前線

椎間板変性治療：Wntシグナル

著者： 檜山明彦¹ 酒井大輔¹ 渡辺雅彦¹

所属機関： ¹東海大学医学部外科学系整形外科

ページ範囲：P.963 - P.970

　椎間板変性は椎間板ヘルニアや脊柱管狭窄，背椎すべり症などの背椎変性疾患のトリガーになりうるが，椎間板変性発症の分子生物学的機序についてはいまだ不明である．椎間板細胞は特異的な微小環境(ニッチ)で生存かつ適応するために独特の制御機構を有するが，そのうちこれらを制御する分子生物学的シグナルのなかでも古典的Wnt/β-cateninシグナルが注目されてきた．これまでの研究からWnt/β-cateninシグナルは椎間板の発生過程や変性過程において重要な役割を果たしていることがわかってきており，今後の椎間板変性に対する治療標的になる可能性が示唆される．

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