臨床整形外科53巻11号

2018年11月発行

誌上シンポジウム 椎間板研究の最前線

椎間板変性治療：抗VEGF・MMP

著者： 大場哲郎¹

所属機関： ¹山梨大学医学部整形外科学講座

ページ範囲：P.981 - P.985

　椎間板変性メカニズムにサイトカインが深く関与していることは古くから研究されており，原因サイトカインの同定は新規治療ターゲットとして有効であり，抗サイトカイン療法として期待されてきた．その中でも血管新生や軟骨基質の分解メカニズムに深く関与するサイトカインである血管内皮細胞増殖因子（VEGF）とマトリックスメタロプロテアーゼ（MMP）はtarget moleculeとして注目されてきた．まだ臨床応用には至っていないが，これまでに多くの研究が報告されている．本稿では当科の研究成果に文献的考察を加えて述べたい．

参考文献

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