臨床整形外科53巻11号

2018年11月発行

誌上シンポジウム 椎間板研究の最前線

椎間板変性治療：多血小板血漿（Platelet-Rich Plasma：PRP）

著者： 須藤隆夫¹ 明田浩司¹ 竹上德彦¹ 佐野友彦¹ 山田淳一¹ 岩崎竜也¹ 舛田浩一² 湏藤啓広¹

所属機関： ¹三重大学大学院医学系研究科運動器外科学 ²カリフォルニア大学サンディエゴ校整形外科

ページ範囲：P.987 - P.991

　椎間板変性は炎症性サイトカインの異常発現を基盤とした組織変性が原因と考えられており，組織断裂に伴う疼痛や変性疾患の発症に関連する．多血小板血漿(PRP)は血小板に含まれる多種のサイトカインや成長因子を高濃度に含有しており，組織再生に臨床応用されている．我々は活性化PRPから得られた上清(PRP上清)が椎間板細胞を活性化し，細胞増殖および基質合成が促進することを報告した．基礎研究結果をもとに椎間板性疼痛患者に対する自己PRP上清注入治療の臨床試験を行い，PRP治療の安全性および予備的な疼痛の改善効果に関して報告する．

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