臨床整形外科53巻12号

2018年12月発行

最新基礎科学/知っておきたい

骨とエクソソーム

著者： 相羽久輝¹²³ 吉田孟史⁴ 山本憲男³ 林克洋³ 荒木麗博²³ 土屋弘行³ 華山力成²⁴

所属機関： ¹名古屋市立大学整形外科 ²金沢大学医学系免疫学 ³金沢大学整形外科 ⁴金沢大学ナノ生命科学研究所

ページ範囲：P.1122 - P.1126

はじめに

　成人骨格は，骨吸収と骨形成からなるリモデリングが内分泌環境や力学的環境などの様々な刺激により調整を受け，ホメオスタシスを保っている¹⁾．この過程において，骨吸収と骨形成は，破骨細胞・骨芽細胞が連関的に働き(カップリング)，この二細胞間や周辺細胞間で相互に情報伝達が行われていると考えられている．近年の研究では，種々の液性因子に加え，エクソソーム(exosome)と呼ばれる細胞外膜小胞が，相互の情報伝達に寄与していると報告されている．今回我々は，現在までに報告されているエクソソームが骨代謝に与える影響を紹介し，今後の展望につき考察する．

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