臨床整形外科54巻12号

2019年12月発行

境界領域/知っておきたい

RS3PE症候群：Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome

著者： 安岡秀剛¹

所属機関： ¹藤田医科大学リウマチ・膠原病内科学講座

ページ範囲：P.1266 - P.1269

はじめに

　RS3PE症候群は，高齢者を中心に関節症状をきたす症例にみられ，しばしばリウマトイド因子・抗CCP抗体陰性の関節リウマチ(RA)(血清陰性関節リウマチ：seronegative RA)，あるいは高齢発症のRA(elderly-onset RA：EORA)，リウマチ性多発筋痛症(polymyalgia rheumatica：PMR)との異同が議論される症候群の1つである．1985年にMcCartyら¹⁾が報告した疾患概念で，Remitting Seronegative Symmetrical Synovitis with Pitting Edema syndromeの略である．直訳すれば，「寛解に向かいつつある，血清反応陰性の対称性滑膜炎で圧痕浮腫を伴う」症候群となる．四肢の比較的大きな関節の炎症を主徴とし，再発は少なく，特に手背・足背の圧痕浮腫が特徴的である．治療としては少量のステロイドが著効を示す．これまでは比較的稀とされてきたが，高齢者の日常診療の中で遭遇する頻度が増え，関節炎の鑑別疾患の1つとして重要となりつつある．

参考文献

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