臨床整形外科55巻4号

2020年04月発行

特集 人工関節周囲感染の現状と展望　国際コンセンサスを踏まえて

人工関節周囲感染に対する分子生物学的迅速診断

著者： 崔賢民¹ 稲葉裕¹

所属機関： ¹横浜市立大学整形外科

ページ範囲：P.329 - P.334

　感染症診断は分子生物学的な技術の進歩により，その感度と迅速性において飛躍的な発展を遂げることが可能となった．人工関節周囲感染患者における感染診断においても，リアルタイムPCRやマルチプレックスPCRによる細菌性DNAの同定，次世代シークエンサーを用いた全網羅的な原因菌の同定，POCT(point of care testing)型遺伝子検査による特定の遺伝子領域の同定は，より高い精度で迅速な診断を可能とすることが期待されている．近年，分子生物学的な手法を用いた診断は，さまざまな分野において感染症診療に不可欠な技術となっており，今後のエビデンスの構築とともに，PJIの診断および治療への応用が期待される．

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