臨床整形外科56巻11号

2021年11月発行

特集 末梢神経の再建2021

人工神経の展望—iPS細胞を付加した人工神経の研究開発

著者： 上村卓也¹² 高松聖仁²³ 中村博亮²

所属機関： ¹JR大阪鉄道病院整形外科 ²大阪市立大学大学院医学研究科整形外科学 ³淀川キリスト教病院整形外科

ページ範囲：P.1343 - P.1348

　末梢神経欠損に対して自家神経移植に代わる神経再生誘導管(人工神経)が開発され，すでに臨床応用されている．しかし，人工神経による神経再生が自家神経移植ほど十分でないため，すべての神経欠損に人工神経の適応があるわけではない．われわれは人工神経による神経再生を促進させるために，人工神経を足場としてiPS細胞由来神経前駆細胞を付加したハイブリッド型人工神経の研究開発を行ってきた．本稿では，幹細胞を付加したハイブリッド型人工神経のなかで，特にiPS細胞ハイブリッド型人工神経に関する基礎研究結果について紹介する．

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