臨床整形外科56巻3号

2021年03月発行

特集 骨折に対する積極的保存療法 基礎編

骨折治癒のプロセスに低出力超音波パルスLIPUSがもたらす治癒促進効果の多様性

著者： 高垣裕子¹

所属機関： ¹神奈川歯科大学大学院口腔科学講座硬組織分子細胞生物学

ページ範囲：P.219 - P.226

　LIPUSの刺激伝達経路には，特に炎症・免疫応答を機転として展開される骨折治癒の過程において，多彩な骨の機能のすべてにわたって驚くほど広範囲にCOX-2/PGE₂による制御が存在する．炎症が全身性に影響を及ぼすこと，その際，力学刺激の存在(全身性には身体活動(active)vs.不活動(inactive)から，局所的には不動(disuse)vs.可動ないし運動(mobileないしlocomotive)が前提になることは，両者においてCOX-2/PGE₂が重要な位置を占めることからも容易に推測できる．単に骨折治癒にとどまらず，LIPUSなどの代替物理刺激はまだまだ可能性を秘めている．

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