臨床整形外科56巻3号

2021年03月発行

特集 骨折に対する積極的保存療法 基礎編

塩基性線維芽細胞増殖因子の骨折治癒過程への影響

著者： 内田健太郎¹

所属機関： ¹北里大学医学部整形外科学

ページ範囲：P.247 - P.251

　手術方法や固定材料の発展により，大多数の骨折症例は治癒可能となった．しかし，遷延治癒や偽関節に至る症例は5〜10％存在する．成長因子を用いた骨折治癒促進効果の検討は1990年代初頭から行われ，これまでに多くの成長因子の効果が検証されてきた．2001年には長管骨の偽関節に対する骨形成蛋白-7(bone morphogenetic protein：BMP-7)の使用，2004年にはBMP-2の脛骨開放骨折への使用がアメリカ食品医薬品局(Food and Drug Administration：FDA)に認可された．一方，日本では2006〜2008年にかけて臨床試験が行われ，脛骨骨折患者に対する塩基性線維芽細胞増殖因子(basic fibroblast growth factor：bFGF)の骨折治癒促進効果が実証された．本稿では，bFGFの骨折治癒過程における役割と骨折治癒促進剤としてのbFGFの作用について概説する．

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