臨床整形外科57巻11号

2022年11月発行

特集 腰椎椎間板ヘルニアのCutting Edge

多血小板血漿を使用した椎間板内治療

著者： 明田浩司¹ 竹上德彦¹ 山田淳一¹ 藤原達彦¹ 湏藤啓広¹

所属機関： ¹三重大学大学院医学系研究科運動器外科学

ページ範囲：P.1301 - P.1306

多血小板血漿(PRP)は多種の生体活性タンパク質を高濃度に含んでおり，再生医療分野にて臨床応用されている．われわれは活性化PRPから抽出したPRP上清を椎間板治療に応用し，その有用性を報告してきた．基礎研究および臨床前研究より，PRP上清が椎間板細胞を活性化し，椎間板変性を再生・修復させる効果があることを示した．そこで慢性腰痛患者(椎間板性疼痛患者)に対して，PRP上清を用いた椎間板内治療の臨床試験を行った．PRP上清は安全性が高く，腰痛に対し効果的な椎間板内治療を展開することが可能である．

参考文献

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