臨床整形外科57巻11号

2022年11月発行

特集 腰椎椎間板ヘルニアのCutting Edge

間葉系幹細胞を用いた椎間板再生

著者： 北原貴之¹ 石黒博之² 海渡貴司¹

所属機関： ¹大阪大学大学院医学系研究科器官制御外科学整形外科学 ²国立病院機構大阪医療センター整形外科

ページ範囲：P.1307 - P.1312

椎間板変性は，腰痛に代表される腰椎疾患の主要な原因と考えられている．変性した椎間板は自然治癒しないため再生治療に期待が寄せられている．椎間板再生治療において細胞治療は中心的役割を担っており，間葉系幹細胞を用いた細胞治療では移植細胞の栄養作用による組織再生効果が報告されている．本総説では，間葉系幹細胞を用いた椎間板再生のアプローチについて用いられる細胞種・担体・作用機序について概説し，われわれが報告してきた脂肪由来間葉系幹細胞由来3次元複合組織による椎間板再生治療についても紹介したい．

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