臨床整形外科57巻6号

2022年06月発行

Lecture

脊髄損傷の病態解明と新規治療法の開発

著者： 小早川和¹ 幸博和¹ 岡田誠司² 前田健³ 中島康晴¹

所属機関： ¹九州大学整形外科 ²大阪大学整形外科 ³総合せき損センター整形外科

ページ範囲：P.809 - P.813

はじめに

　1906年にノーベル生理学・医学賞を受賞したスペインの神経解剖学者Cajal博士により発達後の神経細胞(ニューロン)の成長と再生が否定されて以来，一度傷ついた脊髄は再生不能と考えられてきた．しかし近年の研究により外傷後の脊髄にも実際には可塑性が存在し，組織学的自然修復が起こることが明らかとなった．

　本稿では，近年の研究で明らかになった脊髄損傷後の病態と自然修復メカニズム，およびそれらに基づいて考案された治療法についてわれわれの研究結果も交えて解説する．

参考文献

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