臨床整形外科58巻6号

2023年06月発行

特集 FRIの診断と治療—骨折手術後感染の疑問に答える

骨折内固定材のバイオフィルム感染—エビデンス・コンセンサスと不明点

著者： 梶山史郎¹ 小関弘展² 朝永育³ 尾﨑誠³

所属機関： ¹長崎大学病院整形外科 ²長崎大学大学院医歯薬学総合研究科保健科学分野 ³長崎大学大学院医歯薬学総合研究科整形外科学

ページ範囲：P.751 - P.757

骨折内固定材表面での細菌バイオフィルム形成は，骨折関連感染症を難治化させる主因とされている．近年，細菌バイオフィルムの特性に関する基礎研究が進み，多くの知見が蓄積されている．細菌バイオフィルムに対する抗菌薬の有効性を示す指標として最小バイオフィルム破壊濃度が知られているが，実臨床における骨折関連感染症の病態評価法や治療体系は十分に確立されていない．本稿では，最新のエビデンスとコンセンサスをもとに骨折関連感染症におけるバイオフィルム形成過程，抗菌薬抵抗性，および抗菌薬治療法に関して概説した．

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