臨床整形外科59巻8号

2024年08月発行

特集 脊損患者への投与が始まった脊髄再生医療—脊髄損傷患者に希望が見えるか

HGF Journey from Bench to Clinical Trial—重度頚髄損傷に対する薬剤治療の挑戦

著者： 北村和也¹ 名越慈人² 岡野栄之³ 中村雅也²

所属機関： ¹防衛医科大学校整形外科学講座 ²慶應義塾大学医学部整形外科学教室 ³慶應義塾大学再生医療リサーチセンター

ページ範囲：P.979 - P.988

文献概要

霊長類を含んだ脊髄損傷モデルに対する肝細胞増殖因子(HGF)蛋白髄腔内投与の有効性を明らかとし，2014年より第Ⅰ/Ⅱ相試験(受傷後72時間で改良Frankel分類A/B1/B2を呈する頚髄損傷患者を対象，無作為化，二重盲検，プラセボ対照比較)を行った．安全性および下肢運動機能回復を有意に促進する効果が確認され，2020年から第Ⅲ相試験(HGF単群非盲検)を行った．HGFには単剤での治療効果のみならず，その後の細胞移植やリハビリテーションが開始される際に少しでも良好な脊髄環境を提供するpretreatmentとしての効果も期待される．

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