臨床整形外科59巻8号

2024年08月発行

特集 脊損患者への投与が始まった脊髄再生医療—脊髄損傷患者に希望が見えるか

iPS細胞を用いた脊髄再生医療

著者： 名越慈人¹ 岡野栄之² 中村雅也¹

所属機関： ¹慶應義塾大学医学部整形外科学教室 ²慶應義塾大学再生医療リサーチセンター

ページ範囲：P.995 - P.999

脊髄損傷に対するiPS細胞由来神経前駆細胞を用いた移植治療の確立を目指し，基礎から臨床へと展開している．化学遺伝学の技術を駆使して細胞移植の回復機序を証明し，さらにシナプス形成の促進を図る遺伝子治療の有用性も明らかにしてきた．一方で慢性期の治療は細胞移植だけでなく，宿主の脊髄神経を活性化させるリハビリテーションの併用が極めて重要である．今後も基礎と臨床の両面からのアプローチが，脊髄再生医療の発展に必要である．

参考文献

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12) 名越慈人，岡野栄之，中村雅也．脊髄損傷に対するヒトiPS細胞を用いた細胞移植治療．日医師会誌2022；151(4)：583-6．