臨床整形外科59巻9号

2024年09月発行

特集 変形性関節症に対するBiologics

脂肪由来幹細胞の関節内投与による変形性膝関節症の治療成績と成績に関連する画像所見

著者： 山神良太¹²

所属機関： ¹東京大学整形外科学教室 ²お茶の水セルクリニック

ページ範囲：P.1121 - P.1127

変形性膝関節症(膝OA)に対する間葉系幹細胞の関節内投与が注目されている．われわれは2019年に整形外科領域の細胞治療に特化したお茶の水セルクリニックを設立し，変形性関節症などに対して自己脂肪由来間葉系幹細胞(ASC)の関節内投与を行ってきた．そのうち内反型膝OAに対して行ったASC関節内投与後の治療成績に影響を与える投与前のMRI所見について調査したところ，患者の膝OAの重症度のほかに，大腿骨内側顆の骨髄内病変(BML)のサイズや内側半月逸脱の程度が関連していた．

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