臨床整形外科59巻9号

2024年09月発行

特集 変形性関節症に対するBiologics

脂肪組織由来細胞の作用機序

著者： 蒲地正宗¹ 松下雄彦¹ 松本知之¹ 傍島聰² 黒田良祐¹

所属機関： ¹神戸大学大学院整形外科 ²医療法人再生会そばじまクリニック

ページ範囲：P.1129 - P.1133

近年，再生医療の発展は目覚ましく，臨床応用に向けて研究・開発が行われている．体性幹細胞を利用した細胞療法はその有効性から特に注目されている．さまざまな細胞源があるが侵襲が小さく簡便であること，細胞数が多く含まれるという点から脂肪組織由来細胞は国内外で広く使用されている．整形外科分野においては変形性膝関節症に対して臨床応用されているが，脂肪組織由来細胞の関節症に対する作用機序については未だ不明な点も多い．本稿では変形性膝関節症に対する関節内投与の作用機序を中心に文献的エビデンスも踏まえて概説する．

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