耳鼻咽喉科・頭頸部外科86巻10号

2014年09月発行

特集 咽頭癌・頸部食道癌の治療戦略Update ≪個別化治療の現在≫

PETからみた咽頭癌の個別化治療

著者： 花本敦¹

所属機関： ¹大阪大学大学院医学系研究科耳鼻咽喉科・頭頸部外科学

ページ範囲：P.812 - P.818

POINT

●ワールブルグ効果によって咽頭癌の糖の取り込みは亢進する。

●FDG-PETは普及し3次元解析も一般化。

●MTV，TLGが化学放射線療法の予後を予測する能力が高い。

●治療効果判定としてのPERCISTの評価。

●MTVやPERCISTを用いての個別化治療。

参考文献

1）Warburg O：On the origin of cancer cells. Science 123：309-314, 1956

2）Boellaard R, et al：Effects of noise, image resolution, and ROI definition on the accuracy of standard uptake values：a simulation study. J Nucl Med 45：1519-1527, 2004

3）Kamel EM, et al：Recurrent laryngeal nerve palsy in patients with lung cancer：detection with PET-CT image fusion--report of six cases. Radiology 224：153-156, 2002

4）Salesiotis AN, et al：Molecular markers predictive of response and prognosis in the patient with advanced squamous cell carcinoma of the head and neck：evolution of a model beyond TNM staging. Curr Opin Oncol 12：229-239, 2000

5）Inohara H, et al：Impact of FDG-PET on prediction of clinical outcome after concurrent chemoradiotherapy in hypopharyngeal carcinoma. Mol Imaging Biol 12：89-97, 2010

6）Enomoto K, et al：Prognostic Value of FDG-PET in patients with oropharyngeal carcinoma treated with concurrent chemoradiotherapy. Mol Imaging Biol 10：224-229, 2008

7）Allal AS, et al：Standardized uptake value of 2-［（18）F］fluoro-2-deoxy-D-glucose in predicting outcome inhead and neck carcinomas treated by radiotherapy with or without chemotherapy. J Clin Oncol 20：1398-1404, 2002

8）Schwartz DL, et al：FDG-PET prediction of head and neck squamous cell cancer outcomes. Arch Otolaryngol Head Neck Surg 130：1361-1367, 2004

9）Roh JL, et al：2-［18F］-Fluoro-2-deoxy-D-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx. Eur J Surg Onco 33：790-795, 2007

10）Larson SM, et al：Tumor treatment response based on visual and quantitative changes in global tumor glycolysis using PET-FDG imaging. The visual response score and the change in total lesion glycolysis. Clin Positron Imaging 2：159-171, 1999

11）Lee P, et al：Metabolic tumor burden predicts for disease progression and death in lung cancer. Int J Radiat Oncol Biol Phys 69：328-333, 2007

F］-fluorodeoxyglucose positron emission tomography/computed tomography predicts short-term outcome to radiotherapy with or without chemotherapy in pharyngeal cancer. Clin Cancer Res 15：5861-5868, 2009

13）Hanamoto A, et al：Volumetric PET/CT parameters predict local response of head and neck squamous cell carcinomas to chemoradiotherapy. Cancer Med 2014（in press）

14）Abgral R, et al：Does 18F-FDG PET/CT improve the detection of posttreatment recurrence of head and neck squamous cell carcinoma in patients negative for disease on clinical follow-up? J Nucl Med 50：24-29, 2009

15）Wahl RL, et al：From RECIST to PERCIST：Evolving Considerations for PET response criteria in solid tumors. J Nucl Med 50：122S-150S, 2009

F-FDG PET in managing the neck in node-positive head and neck cancer after chemoradiotherapy. Acta Otolaryngol 129：893-899, 2009

17）Porceddu SV, et al：Utility of positron emission tomography for the detection of disease in residual neck nodes after（chemo）radiotherapy in head and neck cancer. Head Neck 27：175-181, 2005

18）Yanagawa M, et al：Evaluation of response to neoadjuvant chemotherapy for esophageal cancer：PET response criteria in solid tumors versus response evaluation criteria in solid tumors. J Nucl Med 53：872-880, 2012