耳鼻咽喉科・頭頸部外科86巻9号

2014年08月発行

特集 前庭機能検査の新展開

前庭誘発筋電位（VEMP）

著者： 瀬尾徹¹

所属機関： ¹近畿大学医学部耳鼻咽喉科

ページ範囲：P.726 - P.733

文献概要

POINT

●cVEMPは，球形囊-下前庭神経の機能を評価することができる。

●oVEMPは，卵形囊-上前庭神経の機能を評価することができる。

●cVEMPによって，聴神経腫瘍や前庭神経炎の障害部位の推定，内リンパ水腫の推定が可能である。

●oVEMPによって，BPPVの卵形囊障害が推定できる。

●耳石障害によるめまいという新しい疾患概念が確立されつつある。

参考文献

1）Colebatch JG, et al：Vestibular evoked potentials in human neck muscles before and after unilateral vestibular deafferentation. Neurology 42：1635-1636, 1992

2）Murofushi T, et al：Responses of guinea pig primary vestibular neurons to clicks. Exp Brain Res 103：174-178, 1995

3）Murofushi T, et al：Physiological and anatomical study of click-sensitive primary vestibular efferents in the guinea pig. Acta Otolaryngol（Stockh）117：666-672, 1997

4）McCue MP, et al：Spontaneous activity and frequency selectivity of acoustically responsive vestibular afferents in the cat. J Neurophysiol 74：1563-1572, 1995

5）Node M, et al：Frequency dynamics shift of vestibular evoked myogenic potentials in patients with endolymphatic hydrops. Otol Neurotol 26：1208-1213, 2005

6）Rosengren SM, et al：Vestibular-evoked extraocular potentials produced by stimulation with bone-conducted sound. Clin Neurophysiol 116：1938-1948, 2005

7）Iwasaki S, et al：Head taps evoke a crossed vestibulo-ocular reflex. Neurology 68：1227-1229, 2007

8）Curthoys IS et al：Bone conducted vibration selectively activate irregular primary otolith vestibular neurons in the guinea pig. Exp Brain Res 175：256-267, 2006

9）Suzuki JI, et al：Eye movement from single utricular nerve stimulation in the cat. Acta Otolaryngol 68：350-362, 1969

10）Todd NP, et al：Ocular vestibular evoked myogenic potentials（OVEMPs）produced by air- and bone-conducted sound. Clin Neurophysiol 118：381-390, 2007

11）Curthoys IS, et al：The ocular vestibular-evoked myogenic potential to air-conducted sound：probable superior vestibular nerve origin. Clin Neurophysiol 122：611-616, 2011

12）瀬尾　徹：VEMP．JOHNS 27：777-781，2011

13）Saka N, et al：Is a pulling sensation in the anteroposterior direction associated with otolith dysfunction? Acta Otolaryngol 34：233-237, 2014

14）Murofushi T, et al：Vestibular evoked myogenic potentials in patients with acoustic neuromas. Arch Otolaryngol Head Neck Surg 124：509-512, 1998

15）Matsuzaki M, et al：Vestibular evoked myogenic potentials in acoustic tumor patients with normal auditory brainstem responses. Eur Arch Otorhinolaryngol 256：1-4, 1999

16）Suzuki M, et al：Analysis of vestibular testing in patients with vestibular schwannoma based on the nerve of origin, the localization, and the size of the tumor. Otol Neurotol 29：1029-1033, 2008

17）Murofushi T, et al：Absent vestibular evoked myogenic potentials in vestibular neurolabyrinthitis. An indicator of inferior vestibular nerve involvement? Arch Otolaryngol Head Neck Surg 122：845-848, 1996

18）Halmagyi GM, et al：Inferior vestibular neuritis. Ann N Y Acad Sci 956：306-313, 2002

19）de Waele C, et al：Saccular dysfunction in Meniere's disease. Am J Otol 20：223-232, 1999

20）Seo T, et al：A possible case of saccular endolymphatic hydrops. ORL J Otorhinolaryngol Relat Spec 61：215-218, 1999

21）Seo T, et al：Furosemide loading vestibular evoked myogenic potential for unilateral Ménière's disease. Otol Neurotol 24：283-288, 2003

22）Murofushi T, et al：Glycerol affects vestibular evoked myogenic potentials in Meniere's disease. Auris Nasus Larynx 28：205-208, 2001

23）Shojaku H, et al：Clinical usefulness of glycerol vestibular-evoked myogenic potentials：preliminary report. Acta Otolaryngol Suppl 545：65-68, 2001

24）Nakahara H, et al：Damaged utricular function clarified by oVEMP in patients with benign paroxysmal positional vertigo. Acta Otolaryngol 133：144-149, 2013

25）Seo T, et al：Detection of utricular dysfunction using ocular vestibular evoked myogenic potential in patients with benign paroxysmal positional vertigo. Neurosci Lett 550：12-16, 2013

26）Bremova T, et al：Ocular VEMPs indicate repositioning of otoconia to the utricle after successful liberatory maneuvers in benign paroxysmal positioning vertigo. Acta Otolaryngol 133：1297-1303, 2013

27）Lee JD, et al：Abnormality of cervical vestibular-evoked myogenic potentials and ocular vestibular-evoked myogenic potentials in patients with recurrent benign paroxysmal postitional vertigo. Acta Otolaryngol 133：150-153, 2013

28）Roditi RE, et al：Cervical Vesibular evoked myogenic potentials（cVEMPs）in patients with superior canal dehiscence syndrome（SCDS）．Otolaryngol-Head Neck Surg 141：24-28, 2009

29）藤森貴世子・他：上半規管裂隙症候群例．耳鼻臨床106：105-108，2013

30）Seo T, et al：Vestibular evoked myogenic potentials of undiagnosed dizziness. Auris Nasus Larynx 35：27-30, 2008

31）Seo T, et al：Three cases of cochleosaccular endolymphatic hydrops without vertigo revealed by furosemide-loading vestibular evoked myogenic potential test. Otol Neurotol 24：807-811, 2003

32）Murofushi T, et al：Do patients who experience episodic tilting or translational sensations in the pitch plane have abnormal sacculo-collic reflexes? Neurosci Lett 553：95-98, 2013