耳鼻咽喉科・頭頸部外科90巻10号

2018年09月発行

特集 どこが変わった頭頸部癌診療ガイドライン

口腔癌

著者： 朝蔭孝宏¹

所属機関： ¹東京医科歯科大学頭頸部外科

ページ範囲：P.800 - P.805

POINT

●T分類に深達度（depth of invasion：DOI）の概念が追加された。

●アルゴリズムに関しては変更はない。

●クリニカルクエスチョンは倍増した。

●早期舌癌に対する予防的頸部郭清のランダム化試験が行われている。

参考文献

1）Amin MB, et al：AJCC cancer staging manual, 8th ed. Springer, Switzerland, 2017, pp 79-94

2）Brierley JD, et al：TNM classification of malignant tumours, 8th ed. Wiley Blackwell, West Sussex, 2017, pp 18-21

3）日本頭頸部癌学会（編）：頭頸部癌取扱い規約，第6版．金原出版，東京，2018

4）朝蔭孝宏：口腔がん．耳喉頭頸89：1062-1067，2017

5）Spiro RH, et al：Predictive value of tumor thickness in squamous cell carcinoma confined to the tongue and floor of mouth. Am J Surg 152：345-350, 1986

6）Asakage T, et al：Tumor thickness predicts cervical metastasis in patients with stage Ⅰ/Ⅱ carcinoma of the tongue. Cancer 82：1443-1448, 1998

7）International Consortium for Outocome Research（ICOR）in Head and Neck Cancer；Ebrahimi A, et al：Primary tumor staging for oral cancer and a proposed modification incorporating depth of invasion：an international multicenter retrospective study. JAMA Otolaryngol Head Neck Surg 140：1138-1148, 2014

8）Lam P, et al：Correlation MRI and histologic tumor thickness in the assessment of oral tongue cancer. AJR Am J Roentgenol 182：803-808, 2004

9）Shintani S, et al：Intraoral ultrasonography is useful to evaluate tumor thickness in tongue carcinoma. Am J Surg 173：345-347, 1997

10）Paleri V, et al：Sentinel node biopsy in squamous cell cancer of the oral cavity and oral pharynx：a diagnostic meta-analysis. Head Neck 27：739-747, 2005

11）Thompson CF, et al：Diagnostic value of sentinel lymph node biopsy in head and neck cancer：a meta-analysis. Eur Arch Otorhinolaryngol 270：2115-2122, 2013

12）Fasunla AJ, et al：A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck. Oral Oncol 47：320-324, 2011

13）D'Cruz AK, et al：Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med 373：521-529, 2015

14）Patel TD, et al：Efficacy of elective neck dissection in T1/T2N0M0 oral tongue squamous cell carcinoma：a population-based analysis. Otolaryngol Head Neck Surg 155：588-597, 2016

15）Brazilian Head and Neck Cancer Study Group：Results of a prospective trial on elective modified radical classical versus supraomohyoid neck dissection in the management of oral squamous carcinoma. Am J Surg 176：422-427, 1998

16）Licitra L, et al：Primary chemotherapy in resectable oral cavity squamous cell cancer：a randomized controlled trial. J Clin Oncol 21：327-333, 2003

17）Zhong LP, et al：Randomized phase Ⅲ trial of induction chemotherapy with docetaxel, cisplatin and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma. J Clin Oncol 31：744-751, 2013