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雑誌文献

耳鼻咽喉科・頭頸部外科90巻3号

2018年03月発行

文献概要

特集 頭頸部癌に対する薬物療法—最新情報

上咽頭癌に対する化学療法

著者: 古平毅1

所属機関: 1愛知県がんセンター中央病院放射線治療部

ページ範囲:P.228 - P.232

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POINT

●Stage Ⅲ〜ⅣA(UICC 8th)の上咽頭癌は同時併用化学放射線療法が標準だが,Stage Ⅱ(特にN1症例)にも化学療法併用が推奨される。

●強度変調放射線治療により頸部再発率は10%程度に抑えられるようになり,化学療法は遠隔転移制御の役割がより重要となってきた。

●局所進行癌(Stage Ⅲ〜ⅣA)には同時併用法と追加化学療法併用が標準的である。

●再発転移癌への新しい薬物療法の開発が検討されている。

参考文献

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2)Marta GN, et al:Intensity-modulated radiation therapy for head and neck cancer:systematic review and meta-analysis. Radiother Oncol 110:9-15, 2014
3)Chen QY, et al:Concurrent chemoradiotherapy vs radiotherapy alone in stage Ⅱ nasopharyngeal carcinoma:phase Ⅲ randomized trial. J Natl Cancer Inst 103:1761-1770, 2011
4)Du XJ, et al:Circulating EBV DNA, Globulin and Nodal Size Predict Distant Metastasis after Intensity-Modulated Radiotherapy in Stage Ⅱ Nasopharyngeal Carcinoma. J Cancer 7:664-670, 2016
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8)Baujat B, et al:Chemotherapy in locally advanced nasopharyngeal carcinoma:an individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys 64:47-56, 2006
9)Chen L, et al:Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma:a phase 3 multicentre randomised controlled trial. Lancet Oncol 13:163-171, 2012
10)Sun Y, et al:Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma:a phase 3, multicentre, randomised controlled trial. Lancet Oncol 17:1509-1520, 2016
11)Ribassin-Majed L, et al:What Is the Best Treatment of Locally Advanced Nasopharyngeal Carcinoma? An Individual Patient Data Network Meta-Analysis. J Clin Oncol:JCO2016674119, 2016
12)Zhang L, et al:Gemcitabine plus cisplatin versus fluorouracil plus cisplatin in recurrent or metastatic nasopharyngeal carcinoma:a multicentre, randomised, open-label, phase 3 trial. Lancet 388:1883-1892, 2016
13)Lee NY, et al:Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma(RTOG 0615):a phase 2 multi-institutional trial. Lancet Oncol 13:172-180, 2012
14)Chen C, et al:Salvage gemcitabine-vinorelbine chemotherapy in patients with metastatic nasopharyngeal carcinoma pretreated with platinum-based chemotherapy. Oral Oncol 48:1146-1151, 2012
15)Vermorken JB, et al:Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 359:1116-1127, 2008
16)Chan KCA, et al:Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer. N Engl J Med 377:513-522, 2017
17)Huang J, et al:Epstein-Barr virus-specific adoptive immunotherapy for recurrent, metastatic nasopharyngeal carcinoma. Cancer 123:2642-2650, 2017

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1316

印刷版ISSN:0914-3491

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