耳鼻咽喉科・頭頸部外科90巻8号

2018年07月発行

特集 知っておきたい遺伝学的検査と遺伝外来ABC

《遺伝子変異による耳鼻咽喉科疾患》

めまい・平衡障害

著者： 伊藤卓¹

所属機関： ¹東京医科歯科大学耳鼻咽喉科

ページ範囲：P.640 - P.646

文献概要

Point

●めまい診療において，遺伝子の関与を念頭に置いた診療が重要となってきている。

●前庭平衡器には数多くの遺伝子が発現しており，それらの遺伝子の機能欠損から起こる症状はめまい・平衡障害の病態理解に役立つ。

●代表的な耳鼻咽喉科疾患であるメニエール病やめまいを伴う突発性難聴などにおいても，疾患感受性遺伝子の関与が考えられている。

●めまいに関連する遺伝子の研究は，新薬の開発や改良，個別化治療の確立に貢献しうる。

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